CLINACASE

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ID: 242
Category: Gastroenterology and Hepatology
CreatedBy: 1
UpdatedBy: 1
createdon: 14 Jul 2017
updatedon: 17 May 2023

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Author: Khoa Tran
Published Jul 14, 2017
Updated May 17, 2023

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Liver Cirrhosis

Etymology and Pronunciation

cirrhosis (sih-ROH-sis)
kirrhos - Greek for orange-yellow
-osis - Greek suffix for "pathological" or "abnormal condition".

History of Liver Cirrhosis

Even though the microscope was invented in 1590 by two Dutch spectacle-makers and father-and-son team, Hans and Zacharias Janssen, it took until 1667 in Robert Hooke's famous "Micrographia" is published, which outlines Hooke's various studies using the microscope. The usage of the microscope greatly improved the medical understanding of the liver and its diseases. With the microscope, doctors could study the structure and function of the liver on a cellular level, leading to the discovery of liver cells, known as hepatocytes.

As medical technology advanced, further discoveries were made about the pathology of liver diseases, including cirrhosis. In the mid-20th century, advances in imaging technology, such as ultrasound and CT scans, made it possible to better visualize and diagnose cirrhosis.

Today, liver biopsy remains the gold standard for diagnosing cirrhosis, allowing doctors to examine liver cells under a microscope and confirm the presence of fibrosis, or scarring, in the liver. Overall, the development of medical technology has played a critical role in improving the diagnosis and treatment of cirrhosis and other liver diseases.

Modern Understanding of Liver Cirrhosis

Cirrhosis of the liver is a medical condition where the liver becomes permanently damaged and scarred. The liver is a vital organ in the body located in the upper right side of the abdomen, and it plays a crucial role in detoxifying the body and metabolizing nutrients. 

When the liver is damaged, as in cirrhosis, it can lead to a buildup of toxins in the bloodstream, which can cause a range of symptoms. These can include fatigue, weakness, jaundice (yellowing of the skin and eyes), abdominal swelling, and easy bruising or bleeding. 

Cirrhosis can be caused by a variety of factors, such as alcoholism, hepatitis infections, and metabolic disorders. Unfortunately, once the liver is damaged, the scar tissue is permanent, and there is no cure for cirrhosis.

Causes of Liver Cirrhosis

The most common cause of cirrhosis is chronic alcohol abuse, which can cause liver damage and lead to scarring of the liver tissues. Other causes of cirrhosis include chronic viral hepatitis infections (such as Hepatitis B and C), fatty liver disease caused by obesity or diabetes, damage caused by certain medications, and autoimmune liver diseases. In some cases, the cause of cirrhosis is unknown, but it is important to identify and address the underlying cause to prevent further liver damage.

Treatments for Liver Cirrhosis

Cirrhosis of the liver is a serious and irreversible health condition that occurs when liver tissue is damaged and replaced with scar tissue. Treatment for Cirrhosis of the liver depends on the underlying cause and the extent of liver damage.

In most cases, the aim of treatment is to slow the progression of Cirrhosis and manage the symptoms. Treatment options may include lifestyle changes, medication, and in some cases, surgery.

Lifestyle changes may include stopping alcohol consumption, maintaining a healthy diet, and exercising regularly. Avoiding alcohol is particularly important, as it is a common cause of liver damage.

Medications may be used to treat symptoms such as itching, fatigue, and nausea. In some cases, medications may also be used to slow the progression of liver damage or treat underlying causes such as hepatitis or autoimmune diseases.

Surgery may be recommended in severe cases of Cirrhosis, particularly if there is a risk of liver failure or liver cancer. Transplantation surgery may be necessary if the liver is severely damaged or diseased beyond repair. This involves replacing the damaged liver with a healthy liver from a donor.

It is important to note that with proper treatment and management, people with Cirrhosis can live healthy lives. However, early diagnosis and getting the proper treatment is key to successful outcomes. Regular check-ups and follow-ups with a healthcare provider is important for people with Cirrhosis.

Symptoms

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Spider-like blood vessels on the skin
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Memory loss
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Pale-colored stools (poo)
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Dark colored urine/pee
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Yellowing of skin and eyes (jaundice)
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Vomiting
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Weight loss
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Confusion
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Fatigue
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Loss of appetite
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Nausea
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Abdominal tenderness
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Skin dryness
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Joint pain and stiffness
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Tenderness in joints

Confirmation Tests

- Liver function tests
- CT scan
- Blood test
- Liver biopsy

Reference

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