ID: 134
Category: General
CreatedBy: 1
UpdatedBy: 1
createdon: 14 Jul 2017
updatedon: 05 Apr 2023

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Author: Khoa Tran
Published Jul 14, 2017
Updated Apr 05, 2023

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Inflammatory Bowel Disease (IBD)

History of Inflammatory Bowel Disease (IBD)

In the 1920s, a British physician named Sir Arthur Hurst described a case series of patients with a chronic inflammatory condition that affected the colon and rectum. He called this condition "ulcerative colitis" based on the presence of ulcerations in the colon lining.

Around the same time, a group of American physicians, led by Burrill B. Crohn, observed a distinct set of symptoms in some patients with bowel inflammation that did not fit the typical profile of ulcerative colitis. These patients had inflammation that affected the entire thickness of the bowel wall, rather than just the surface, and could involve any part of the digestive tract, from the mouth to the anus.

Crohn and his colleagues described the disease as a distinct entity and named it "regional enteritis" later renamed as Crohn's disease.

Modern Understanding of Inflammatory Bowel Disease (IBD)

Inflammatory bowel disease (IBD) is a type of gastrointestinal disorder that causes chronic inflammation of the digestive tract. This can lead to a variety of symptoms, including abdominal pain, bloating, diarrhea, constipation, alternating diarrhea and constipation, mucus in the stool, gas, stomach cramps, bowel urgency, and bowel incontinence.

Many people with IBD also experience food intolerances, psychological stress, and hormonal changes, which can exacerbate their symptoms. Other conditions, such as small intestine bacterial overgrowth (SIBO) and gastroesophageal reflux disease (GERD), can also contribute to symptoms similar to those of IBD.

Causes of Inflammatory Bowel Disease (IBD)

The exact cause of IBD is not known, but researchers believe that a combination of genetic, environmental, and immune system factors play a role.

- Genetics: A family history of IBD is one of the most significant risk factors for developing the disease. Studies have shown that certain genes can increase the likelihood of developing IBD, and people with a first-degree relative (parent, sibling, or child) with IBD are at higher risk of developing the disease.
- Environmental Factors: Environmental factors such as smoking, diet, and infections may also contribute to the development of IBD. Studies have shown that smoking can increase the risk of developing Crohn's disease, while a diet high in fat and processed foods may increase the risk of developing ulcerative colitis.
- Abnormal Immune System Response: Researchers believe that an abnormal immune system response may also play a role in the development of IBD. In people with IBD, the immune system attacks the digestive system, causing inflammation and damage to the intestinal lining. This can lead to symptoms such as diarrhea, abdominal pain, and weight loss.
- Microbial Imbalance: There is growing evidence that an imbalance in the gut microbiota may contribute to the development of IBD. The gut microbiota is a complex ecosystem of microorganisms that live in the digestive system and play a critical role in digestion and immune system function. Studies have shown that people with IBD have an altered gut microbiota, which may contribute to the development of the disease.
- Stress: While stress does not cause IBD, it can exacerbate symptoms and trigger flare-ups in people who already have the disease. Researchers believe that stress may affect the immune system and increase inflammation in the digestive system, leading to symptoms such as abdominal pain and diarrhea.

Treatments for Inflammatory Bowel Disease (IBD)

Treatment for IBD typically involves a combination of medication, lifestyle changes, and sometimes surgery. The specific treatment approach will depend on the type and severity of the disease, as well as the individual's overall health and preferences.

- Medications: There are several types of medications used to treat IBD, including anti-inflammatory drugs, immunosuppressants, and biologic therapies. Anti-inflammatory drugs such as aminosalicylates can help reduce inflammation in the digestive system and relieve symptoms. Immunosuppressants such as azathioprine and methotrexate can help suppress the immune system and reduce inflammation. Biologic therapies such as infliximab and adalimumab target specific proteins in the immune system that contribute to inflammation.
- Lifestyle Changes: Certain lifestyle changes can help manage symptoms and improve overall health in people with IBD. These include maintaining a healthy diet, getting regular exercise, avoiding smoking, managing stress, and getting enough sleep. Some people with IBD may also benefit from working with a dietitian or nutritionist to develop a personalized nutrition plan.
- Surgery: In some cases, surgery may be necessary to manage complications of IBD or to improve quality of life. Surgery may involve removing part or all of the colon (colectomy) or creating an opening (ostomy) in the abdominal wall to allow for the elimination of waste.
- Alternative Therapies: Some people with IBD may find relief from complementary or alternative therapies such as acupuncture, probiotics, and herbal supplements. While these therapies may help manage symptoms for some people, it's important to discuss their use with a healthcare provider to ensure they are safe and effective.


Abdominal pain
Loss of appetite
Weight loss

Confirmation Tests

- Stool test
- Blood test
- Colonoscopy
- CT scan
- Upper endoscopy

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