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IgA nephropathy, also known as Berger's disease, is a type of kidney disease that occurs when a protein called immunoglobulin A (IgA) builds up in the kidneys. This can lead to inflammation and damage to the kidneys, which can affect their ability to function properly. IgA nephropathy is one of the most common types of glomerulonephritis, a group of diseases that affect the glomeruli, the tiny filters in the kidneys that remove waste and excess fluids from the blood. The exact cause of IgA nephropathy is not fully understood, but it is thought to be related to an abnormal immune response in the body. It may also be influenced by genetic factors and certain infections. Common symptoms of IgA nephropathy include blood in the urine, foamy urine due to excess protein, swelling in the hands, feet, and face, high blood pressure, fatigue or weakness, reduced urine output, back pain, and nausea or vomiting. Some people with IgA nephropathy may have no symptoms in the early stages of the disease, making it difficult to diagnose. Treatment for IgA nephropathy depends on the severity of the condition and may include medications to reduce inflammation and control blood pressure, dietary changes to manage protein and sodium intake, and lifestyle modifications to promote kidney health. In some cases, more aggressive treatments such as immunosuppressive medications or plasma exchange may be required. If left untreated, IgA nephropathy can lead to chronic kidney disease or kidney failure. It is important to seek medical attention if you experience any symptoms or if you have a family history of kidney disease. A healthcare provider can perform tests to diagnose the condition and recommend appropriate treatment options.