ID: 254
Category: Endocrinology
CreatedBy: 1
UpdatedBy: 1
createdon: 25 May 2023
updatedon: 25 May 2023

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Author: Khoa Tran
Published May 25, 2023
Updated May 25, 2023

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Etymology and Pronunciation

Hypopituitarism (hypo-pi-too-uh-tuh-riz-um)
hypo- - Greek prefix for "under" or "below normal"
pituita - Latin for "phlegm"
-ism - Suffix. Indicates a specific condition or state.

History of Hypopituitarism

Hypopituitarism is a medical condition characterized by reduced or complete loss of function of the pituitary gland. The pituitary gland is an important endocrine gland that plays a critical role in regulating various hormonal processes in the body.

Hypopituitarism was first descripted in 1914 by Morris Simmonds, earning it the name Simmonds' disease. It is a condition characterized by diminished function of the pituitary gland

Throughout history, the hypofunction of the pituitary gland has been attributed to two main factors. Firstly, it can arise from direct dysfunction of the pituitary gland itself. Secondly, it can result from damage to the hypothalamus, a region of the brain responsible for regulating hormone production. In both cases, the production of pituitary hormones becomes compromised.

One of the major discoveries that led to a better understanding of hypopituitarism was the identification of the pituitary gland as the central gland of the endocrine system. This was made possible through the use of technologies like microscopy and improved anatomical studies of the human body.

Another important discovery was the isolation and characterization of the hormones produced by the pituitary gland. This was achieved through the development of radioimmunoassay techniques, which paved the way for researchers to better understand the role of the pituitary gland in regulating hormonal balance in the body.

More recently, advances in brain imaging technologies like magnetic resonance imaging (MRI) have allowed researchers to visualize the structure and function of the pituitary gland more clearly. This has improved our understanding of the underlying causes of hypopituitarism and has led to the development of more effective diagnostic and treatment strategies for this condition.

Modern Understanding of Hypopituitarism

Hypopituitarism is a medical condition that affects the pituitary gland in the brain. This gland is responsible for producing hormones that regulate different bodily functions such as growth, metabolism, and reproduction. When this gland does not produce enough hormones, it can lead to several health complications. Hypopituitarism can affect people of all ages, and it may happen suddenly or gradually develop over time. 

People with hypopituitarism may experience symptoms such as fatigue, weakness, loss of appetite, weight loss, and decreased sexual function. These symptoms may vary depending on the hormones that are lacking in the body. For example, if the body is not producing enough growth hormone, individuals may experience stunted growth, slow bone development, and delayed puberty. 

It is important to get a proper diagnosis of hypopituitarism, as it can lead to serious health complications if left untreated. Doctors may conduct tests to determine if the pituitary gland is functioning properly or if there is an underlying condition causing hypopituitarism.

Causes of Hypopituitarism

Congenital causes:

- Idiopathic: In some cases, hypopituitarism may occur without any apparent anatomical lesion or association with syndromic disease. The exact cause remains unknown.
- Anatomic Lesions in the Sella Region: Certain structural abnormalities in the sella region, such as primary empty sella syndrome (a condition where the sella turcica is partially or completely filled with cerebrospinal fluid) or Rathke's cyst (a benign cyst derived from remnants of the Rathke's pouch), can disrupt pituitary function.
- Malformations of the Central Nervous System: Certain congenital malformations of the central nervous system can be associated with hypopituitarism. Examples include septo-optic dysplasia (a condition characterized by underdevelopment of the optic nerve and absence of the septum pellucidum), Kallmann syndrome (a genetic disorder characterized by delayed or absent puberty and a lack of sense of smell), and pituitary stalk interruption syndrome (a condition where the pituitary stalk fails to develop properly).


- Pituitary Tumor: The presence of a pituitary tumor, particularly a macroadenoma (large tumor), can compress the surrounding pituitary tissue, leading to hormone deficiencies.
- Craniopharyngeoma: This is a benign tumor that develops near the pituitary gland, often in the region of the hypothalamus. Its growth can interfere with pituitary function.
- Hypothalamo-Pituitary Surgery: Surgical procedures, such as transsphenoidal or transcranial surgery performed in the hypothalamo-pituitary region, can inadvertently damage the pituitary gland or disrupt its blood supply, resulting in hypopituitarism.
- Cranial Radiation: Patients who receive radiation therapy to the head or cranial area, particularly for the treatment of brain tumors, may develop hypopituitarism as a long-term side effect.
- Systemic Cancer Treatment: Some chemotherapeutic agents used to treat systemic cancer can affect the function of the pituitary gland.
- Traumatic Brain Injury: Severe head trauma, such as a traumatic brain injury, can disrupt the normal functioning of the pituitary gland and result in hypopituitarism.
- Sheehan's Syndrome: This condition occurs when the pituitary gland suffers ischemic necrosis due to severe bleeding during childbirth or postpartum hemorrhage, leading to inadequate hormone production.
- Apoplexy: Pituitary apoplexy refers to the sudden bleeding or infarction (tissue death due to interrupted blood supply) of a pituitary tumor or the pituitary gland itself. This can cause acute hormonal deficiencies.
- Subarachnoid Hemorrhage: A subarachnoid hemorrhage refers to bleeding in the space between the brain and the thin tissues covering the brain (subarachnoid space). If this bleeding affects the pituitary gland or disrupts its blood supply, it can lead to hypopituitarism.
- Meningitis: Meningitis is an inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. In some cases, the infection or inflammation can extend to the pituitary gland, causing damage and impairing hormone production.
- Hypophysitis: Hypophysitis refers to inflammation of the pituitary gland itself. This condition can result from various causes, including autoimmune disorders, infections, or certain medications. The inflammation can lead to pituitary dysfunction and subsequent hypopituitarism.
- Meningioma in the Sella Region: A meningioma is a tumor that arises from the meninges, the membranes that cover the brain and spinal cord. When a meningioma develops in the sella region, which houses the pituitary gland, it can exert pressure on the pituitary and disrupt its normal function.
- Lymphoma: Lymphoma is a type of cancer that affects the lymphatic system. In some cases, lymphoma can involve the pituitary gland, leading to its dysfunction and hypopituitarism.
- Wegener's Granulomatosis: Wegener's granulomatosis, now known as granulomatosis with polyangiitis, is a rare autoimmune disease characterized by inflammation of blood vessels. In rare instances, it can involve the pituitary gland and cause hypopituitarism.
- Hemochromatosis: Hemochromatosis is a hereditary disorder characterized by excessive iron absorption and deposition in various organs, including the pituitary gland. Iron overload in the pituitary can impair its function and result in hypopituitarism.

It's important to note that while these are potential causes of hypopituitarism, not every case of hypopituitarism will be attributed to these specific factors. Diagnosing the underlying cause of hypopituitarism requires a thorough evaluation by a medical professional, including medical history, physical examination, and potentially additional tests such as imaging studies or blood tests.

Treatments for Hypopituitarism

The type treatment will depend on which specific hormones are deficient. Some commonly used hormones include:

- Cortisol: This hormone is produced by the adrenal gland and is important for regulating blood sugar levels, blood pressure, and the immune system.
- Thyroid hormone: This hormone regulates metabolism and energy levels.
- Testosterone/Estrogen: These hormones are important for sexual development and reproductive health.
- Human growth hormone (hGH): This hormone is important for growth and development in children, and for maintaining muscle mass and bone density in adults.
- Antidiuretic hormone (ADH): This hormone controls water balance in the body.

In addition to hormone replacement therapy, lifestyle changes such as a healthy diet, regular exercise, and stress management can also be beneficial. In some cases, surgery may be necessary to remove tumors or correct other underlying conditions that are causing the hypopituitarism. It is important to work with a healthcare provider to develop an individualized treatment plan for hypopituitarism.

Lifestyle Changes

While lifestyle changes alone may not treat the underlying cause of hypopituitarism, they can play a supportive role in managing the condition and improving overall well-being. Here are some lifestyle changes that may be beneficial:

- Medication Adherence: If you are prescribed hormone replacement therapy to manage the deficiencies caused by hypopituitarism, it is crucial to take the medications as prescribed. Adhering to the recommended dosage and schedule will help maintain hormone balance and manage symptoms.
- Regular Medical Check-ups: Schedule regular follow-up appointments with your healthcare provider to monitor your hormone levels and overall health. This allows for adjustments in medication dosages if necessary and ensures proper management of hypopituitarism.
- Balanced Diet: Adopting a balanced and nutritious diet can support overall health and potentially improve hormone regulation. Include a variety of fruits, vegetables, whole grains, lean proteins, and healthy fats in your meals. Consult a registered dietitian or nutritionist for personalized dietary recommendations.
- Exercise: Engaging in regular physical activity can have numerous benefits, including improved cardiovascular health, weight management, and mood regulation. Consult your healthcare provider for exercise recommendations suitable for your specific condition and fitness level.
- Stress Management: Chronic stress can negatively impact hormone regulation and overall health. Incorporate stress management techniques into your routine, such as meditation, deep breathing exercises, yoga, or engaging in activities you enjoy. Prioritize self-care and find healthy ways to cope with stress.
- Sleep Hygiene: Prioritize quality sleep and establish a consistent sleep routine. Aim for the recommended 7-9 hours of uninterrupted sleep per night. Create a relaxing sleep environment, limit exposure to electronic devices before bedtime, and avoid stimulants like caffeine close to bedtime.
- Supportive Relationships: Surround yourself with a supportive network of family, friends, or support groups. Sharing your experiences, concerns, and emotions with others who understand your condition can provide emotional support and help you navigate the challenges of hypopituitarism.
- Manage Other Health Conditions: Hypopituitarism may be associated with other health conditions, such as thyroid disorders or adrenal insufficiency. Properly managing these conditions through medication, lifestyle modifications, and regular medical follow-ups is essential for overall well-being.

Remember, lifestyle changes should always be discussed with your healthcare provider, as they can provide personalized guidance based on your specific condition and needs.


Decreased libido
Delayed growth and development in children
Hair loss
Slower than normal heart beat (below 60 beats/minute)
Heavy or irregular periods
Skin dryness
Cold intolerance
Weak pulse / low blood pressure
Muscle Weakness

Confirmation Tests

- Blood test
- Stimulation tests
- CT scan